I mostly do. That sounds pretty indiscriminate, but I have read widely and studied the kind of craft which can apply to all stories (structure, pacing, character arcs, tone). I used to be more leery of genres like memoir and thriller, but when I took them on, the authors reinforced me by letting me know how useful the feedback was. I also learn a lot, and keep my mind sharp, by working across a variety of genres
My motto is "Keep moving forward." Keep learning and growing!
That said, I've become known for my SFF work, and most of my clients come in with that :)
How do you know when a book is right for you to edit? Do you take on anyone who hires you?